Tinospinosides D, E, and tinospin E, further clerodane diterpenoids from Tinospora sagittata.
نویسندگان
چکیده
Chemical investigation on the roots of Tinospora sagittata resulted in the isolation of three novel cis-clerodane diterpenoids, tinospinosides D, E, and tinospin E, together with two known compounds, columbin and columbin glucoside, and their structures were determined by extensive spectroscopic analyses, chemical reactions and computer-assisted calculations. The inhibitory activity of the isolated compounds and their chemical derivatives on nitric oxide production in lipopolysaccharide and interferon-γ activited J774.1 macrophage-like cells was also evaluated.
منابع مشابه
Two New Clerodane Diterpenes from Tinospora sagittata.
Two new clerodane-type diterpenes, tinosporins C (1) and tinosporins D (2) were isolated from the stems of Tinospora sagittata (Oliv.), together with three known ones, columbin (3), tinophylloloside (4), and tinospinoside D (5). The structures of these compounds were determined on the basis of spectroscopic data interpretation, with that of the absolute configuration of compound 1 was assigned ...
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 60 10 شماره
صفحات -
تاریخ انتشار 2012